The study is devoted to the recognition of the 'high quality fakes' and addresses two important issues. The first one is the possibility of applying the NIR/chemometric approach for detection of the injection remedy, which is a water solution with low concentration of active ingredients, directly in the closed ampoules. The second issue is the comparison of the NIR/chemometric conclusions with the detailed chemical analysis. In this study we have shown that a low selective method such as NIR spectrometry can discriminate very similar objects and may be applied for a rapid screening. NIR results were confirmed by HPLC-DAD-MS and capillary electrophoresis analysis. These methods are much more time consuming and may be applied to the suspicious objects revealed by NIR/chemoemetric approach.

The study was caused by a strange particular case when a counterfeited remedy was revealed by manufacturer with the help of special hidden marks on a package, but the standard GC pharmocopic test could not recognize the forgery.